I think I might have seen that movie in first-semester organic...
- Sara Davis, GlaxoSmithKline - US
Sara K. Davis
Information Manager, Intellectual Property
Corporate Intellectual Property – Upper Merion
GlaxoSmithKline - US
Phone: (610)-270-6416
e-mail: Sara.K.Davis@gsk.com
"Shobe, Dave" <dshobe@sud-chemieinc.com>
Sent by: owner-piug-l@derwent.co.uk
19-Apr-2002 08:38
To: "'PIUG-L'"
cc:
Subject: RE: Funny CAS title
Just for fun I did a Google search for "aminals" and all of the first 20
hits appear to be misspellings (intentional or not) of "animals". For
Scirus, the first 10 hits were split 50-50.
If someone made a movie illustrating the mechanism of the reaction:
CH3CH2X + NH2CH3 --> CH3CH2NHCH3 + HX
I suppose this would be an animation of an amination. :-)
--David Shobe
Süd-Chemie Inc.
phone (502) 634-7409
fax (502) 634-7724
email dshobe@sud-chemieinc.com
Don't bother flaming me: I'm behind a firewall.
-----Original Message-----
From: Robert Buntrock [mailto:buntrock2@earthlink.net]
Sent: Thursday, April 18, 2002 5:47 PM
To: Joerg Ohms; PIUG-L@derwent.co.uk
Subject: Re: Funny CAS title
Joerg Ohms wrote:
>
> The US application US 2002028836 (original title: "Potassium channel
> openers") mentions in its abstract "a method of opening potassium
channels
> in a mammal". CAS enlightens the real content by formulating the title
> "Preparation of aminals and derivatives and their therapeutic uses as
> potassium channel openers" (AN 2002:172495). CAS identified the
"prepn. of
> aminals" as a central claim of this patent application an included
this
> into the IT fields of this document.
>
> Is this a joke? Problems within the (automatic?) indexing process?
What
> about quality control during the production of new database documents?
-
> Any explanation from CAS would be welcomed.
Joerg, et al.
Sorry to disappoint you and all of the responders, but if the patent
does indeed describe preparation of aminals (spelling as such and not
animals), it is correct and not funny, at least for the reasons you
infer. Aminals are acceptable generic nomenclature for compounds
formally (but not necessarily in actuality) derived from carboxylic acid
amides. Probably the most common example is dimethylformamide dimethyl
acetal, aka 1,1-dimethoxytrimethylamine, (CH3)2NCH(OCH3)2, available
from Aldrich, cat. no. 39,496-3 or 14,073-2. It's used as a formylating
agent or as a derivitizing agent to prepare amidines from primary
amines.
Bottom line: aminal may be a difficult to recognize anagram of animal,
but it's legitimate nomenclature.
When I first started using this reagent in the mid-60s in grad school,
we had to make our own. Shortly thereafter, it became commercially
available through Aldrich so that when I made prepared amidines in first
non-academic job, I was able to save time and effort and bought it.
The first clue to the reality of this patent disclosure should have been
preparation of aminals. Anything claiming preparation of animals (even
cloning shouldn't really be considered "preparation"), would have indeed
been a hoot. So, Bill et al., go ahead and enjoy your animal crackers.
Aminal crackers would indeed by very exotic -- and probably noxious and
toxic.
-- Bob Buntrock
Buntrock Associates, Inc.
PS: For documentation on my grad school research, cf. my PhD thesis,
Princeton Univ., 1967. Unfortunately, I don't believe my similar work
at Air Products and Chemicals was ever patented (and certainly was never
published).
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